Microglial control of neuronal activity
نویسندگان
چکیده
منابع مشابه
Microglial control of neuronal activity
Fine-tuning of neuronal activity was thought to be a neuron-autonomous mechanism until the discovery that astrocytes are active players of synaptic transmission. The involvement of astrocytes has changed our understanding of the roles of non-neuronal cells and shed new light on the regulation of neuronal activity. Microglial cells are the macrophages of the brain and they have been mostly inves...
متن کاملOptimal control of neuronal activity.
We investigate the optimal control of neuronal spiking activity for neurons receiving a class of random synaptic inputs, characterized by a positive parameter alpha. Optimal control signals and optimal variances are found exactly for the diffusion process approximating an integrate and fire model. When synaptic inputs are "sub-Poisson" (alpha<0.5), we find that the optimal synaptic input is a d...
متن کاملNeuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus.
Microglia are highly dynamic immune cells of the CNS and their dynamism is proposed to be regulated by neuronal activities. However, the mechanisms underlying neuronal regulation of microglial dynamism have not been determined. Here, we found an increased number of microglial primary processes in the hippocampus during KA-induced seizure activity. Consistently, global glutamate induced robust m...
متن کاملA pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation.
Recent studies have demonstrated that activated microglia play an important role in dopamine (DA) neuronal degeneration in Parkinson disease (PD) by generating NADPH-oxidase (NADPHO)-derived superoxide. However, the molecular mechanisms that underlie microglial activation in DA cell death are still disputed. We report here that matrix metalloproteinase-3 (MMP-3) was newly induced and activated ...
متن کاملLPS-induced microglial secretion of TNFα increases activity-dependent neuronal apoptosis in the neonatal cerebral cortex.
During the pre- and neonatal period, the cerebral cortex reveals distinct patterns of spontaneous synchronized activity, which is critically involved in the formation of early networks and in the regulation of neuronal survival and programmed cell death (apoptosis). During this period, the cortex is also highly vulnerable to inflammation and in humans prenatal infection may have a profound impa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2013
ISSN: 1662-5102
DOI: 10.3389/fncel.2013.00032